The clinicopathological features of classical high-grade FH-deficient RCC are now well known, and the typical high-grade morphology region in the rare coexisting tumors of low-grade and high-grade morphology has a certain suggestive significance for the diagnosis of this tumor, and is similar to the poor prognosis of tumors with pure high-grade morphology (4, 6), which will not be repeated in this paper. The gene discussed is FH; the disease is renal cell carcinoma.