FH-deficient renal cell carcinoma is pathologically arranged in a variety of structures, and the classical histological images show a high-level morphology: cells with abundant cytoplasm and large nuclei, with prominent viral inclusion body-like eosinophilic macronuclei and perinuclear empty halos seen in some cases (2), which is suggestive of the diagnosis of this tumor. The gene discussed is FH; the disease is renal cell carcinoma.