KRAS and ovarian serous adenocarcinoma: While low-grade serous ovarian cancers exhibit high frequencies of KRAS Proto-Oncogene, GTPase (KRAS) and B-Raf Proto-Oncogene, Serine/Threonine Kinase (BRAF) oncogene mutations, HGSOC is characterized by a prevalence of p53 and tumor suppressor mutations alongside the absence of KRAS/BRAF mutations 7.