To elucidate the molecular underpinnings of cdkn2b-/-/tp53-/- Xenopus tropicalis melanoma development, we systematically collected samples including cdkn2b-/-/tp53-/- Xenopus tropicalis benign nevi adjacent tissues (BNC), benign nevi (BN), dysplastic nevi (DN), invasive melanoma (IM), and adjacent invasive melanoma tissues (IMC) for Bulk RNA-seq analysis (Figure 5A). Here, CDKN2B is linked to dysplastic nevus.