The incidence of spontaneously developing melanoma in 2-year-old cdkn2b-/-/tp53-/- Xenopus tropicalis reaches as high as 81%, and the pathological features of cdkn2b-/-/tp53-/- Xenopus tropicalis melanoma are similar to those of human CDKN2A-HM. Here, CDKN2B is linked to melanoma.