This suggests that akin to BRAFV600E-driven melanoma, during the development of cdkn2b-/-/tp53-/- Xenopus tropicalis melanoma, melanoma cells undergo dedifferentiation, adopting the transcriptional state of pigment cell progenitors, undergo EMT, culminating in invasive melanoma (Figure 7I). The gene discussed is CDKN2B; the disease is melanoma.