MAPT and Obesity: While obesity in the presymptomatic stage of the disease had pernicious effects, as manifested by attenuated hippocampal glucose uptake and decreased resting cerebral perfusion; obesity during the symptomatic stage of AD prevented the disease-dependent decrease in hippocampal glucose uptake and cerebrovascular reactivity, despite unabated progression in amyloid and tau pathologies, as seen by our accompanying study in the same animals 46.