With prolonged exposure to HCHF diet, female TgAD rats did show attenuation of hippocampal AQP4 density (significant interactions of diet-genotype-sex: 20 ± 5%, P < 0.001; genotype-sex: -17 ± 3%, P < 0.001; age-genotype: -14 ± 4%, P < 0.001; and genotype: 12 ± 2%, P < 0.001) and an accompanying increase in cerebral amyloid angiopathy (significant age and sex interaction: -0.4 ± 0.2%, P = 0.004; and age effect: 0.5 ± 0.1%, P < 0.001) (Figure 7C). This evidence concerns the gene AQP4 and cerebral amyloid angiopathy.