Rats fed a low-fat diet supplemented with BCAAs do not develop insulin resistance.30 Several studies suggested that BCAA supplementation or BCAA-rich diets are beneficial for promoting lean body mass in obesity or catabolic disorders or for increasing satiety for body weight loss.29 A study on the synergistic effect of exercise and BCAAs on brain structure and function found that BCAA and exercise decreased body weight, decreased fasting insulin levels, and improved circadian rhythms. Here, INS is linked to Obesity.