One study reported the development of a hydrogel based on STING (stimulator of interferon genes) agonists to promote immune activation, thereby enhancing the efficacy of radiofrequency ablation for hepatocellular carcinoma and effectively inhibiting the proliferation and metastasis of residual tumors caused by incomplete radiofrequency ablation 26. This evidence concerns the gene STING1 and hepatocellular carcinoma.