LEAP2 and obesity due to melanocortin 4 receptor deficiency: In the present study in obesity and T2DM, there was no correlation between BMI and the postprandial increase in plasma LEAP2 across all visits over 50 weeks in the subgroup having the fixed meal, in contrast to other studies reporting that higher BMI is associated with lower postprandial increases in plasma LEAP2 in adults without obesity or T2DM [42], but with higher postprandial plasma LEAP2 across 2 discrete groups with normal weight and obesity without T2DM [17].