DJBL insertion in obesity/T2DM delayed and attenuated the weight loss–associated decrease in fasting plasma LEAP2 through uncertain mechanisms, which might have contributed to the greater weight loss after DJBL insertion, through attenuation of GHSR signaling, although differences in eating behavior or dietary intake between the 2 groups have not been identified. The gene discussed is GHSR; the disease is obesity due to melanocortin 4 receptor deficiency.