Comparing results across different human studies (overall 3 without obesity, 6 with obesity, including the present study) [17, 34, 36, 43, 44, 50, 51], there was a suggestion that the absolute postprandial increase in plasma LEAP2 is proportional to the preload fixed meal energy intake (rS = +0.59; P = .17) (see Fig. 4F, Supplementary Table S25 [63]). Here, LEAP2 is linked to obesity due to melanocortin 4 receptor deficiency.