INS and obesity due to melanocortin 4 receptor deficiency: In the present study of obesity with T2DM, fasting plasma LEAP2 over the 2-year period in the SMM group was positively correlated with fasting plasma glucose, HbA1c, serum insulin and triglycerides, and HOMA-IR for absolute plasma LEAP2, and decreases in plasma LEAP2 positively correlated with decreases in fasting plasma glucose, HbA1c, and HOMA-IR.