LEAP2 and obesity due to melanocortin 4 receptor deficiency: Furthermore, fasting plasma LEAP2 positively correlated with fasting serum triglycerides in adults with normal weight/overweight/obesity [17], and in overweight/obesity with prediabetes [67], but not in adults with T2DM without obesity [47], while postprandial increases in plasma LEAP2 tended to negatively correlate with postprandial increases in triglycerides in adults without obesity or T2DM [42].