LEAP2 and obesity due to melanocortin 4 receptor deficiency: Contrary to our hypothesis in the present study, there were no correlations between absolute/changes in fasting or postprandial plasma LEAP2 with absolute/changes in fasting hunger/appetite or postprandial fullness/appetite ratings in adults with obesity and T2DM in either the SMM or DJBL groups at baseline or across all visits, nor any differences between the groups.