Contrary to our hypothesis in the present study, there were no correlations between absolute/changes in fasting or postprandial plasma LEAP2 with absolute/changes in fasting hunger/appetite or postprandial fullness/appetite ratings in adults with obesity and T2DM in either the SMM or DJBL groups at baseline or across all visits, nor any differences between the groups. The gene discussed is LEAP2; the disease is type 2 diabetes mellitus.