LEAP2 and obesity due to melanocortin 4 receptor deficiency: Several single time point cross-sectional studies have also found positive correlations between fasting plasma LEAP2 and BMI, in adults across a range of BMIs from normal weight to obesity, mainly without T2DM [17], overweight/obesity and T2DM [43, 66], overweight with MAFLD [46], obesity and prediabetes [67], and with percentage body fat, visceral adiposity, and liver fat [17, 46, 67], though these positive correlations with BMI or percentage body fat were not seen in one study of adults with overweight/obesity [48].