NPPB and COVID-19: The mechanisms of heart failure can be attributed to an imbalance between increased cardiac output and reduced oxygen supply, with the possibility for type 2 myocardial infarction.72 According to Li and al.,39 NT-Pro-BNP>500pg/L were significantly associated with severe forms of COVID-19, and Hong and al.,10 demonstrated that critically ill patients had higher NT-Pro-BNP levels (p=0.002).