AT-rich interactive domain-containing protein 1A is a mutated tumor suppressor gene in hepatocellular carcinoma, and the data of Xing T et al. found that loss of this gene shifted the glucose metabolism of tumor cells from glycolysis to TCA cycle and oxidative phosphorylation (OXPHOS), which upregulated FDX1 and lipoylated proteins and exhibited greater sensitivity to Cu stress in tumor cells (Xing et al., 2023). Here, FDX1 is linked to hepatocellular carcinoma.