For instances, in Wilson disease and Menkes disease, the pathogenic variants of ATP7A/7B disturb the intracellular Cu content and homeostasis, the treatment is to recover normal intracellular Cu content (Wilson, 1934; Danks et al., 1972); in tumoral diseases, mounting evidences suggest that Cu dyshomeostasis plays a prominent role in energy metabolism and angiogenesis, the treatment targets oxidative stress, mitochondrial respiration, UPS and angiogenesis using Cu complexes (Ge et al., 2022). This evidence concerns the gene ATP7A and Menkes disease.