For instances, the phosphodiesterase 3B has been confirmed to increase the sensitivity of Cu ionophore to bladder cancer cells (Feng et al., 2024); the methyltransferase METTL16 is reported to promote FDX1 mRNA stability via m6A modification and FDX1 accumulation to enhance the sensitivity of elesclomol treatment in gastric cancer (Sun et al., 2023). Here, METTL16 is linked to urinary bladder cancer.