ATP7A and Wilson disease: For instances, in Wilson disease and Menkes disease, the pathogenic variants of ATP7A/7B disturb the intracellular Cu content and homeostasis, the treatment is to recover normal intracellular Cu content (Wilson, 1934; Danks et al., 1972); in tumoral diseases, mounting evidences suggest that Cu dyshomeostasis plays a prominent role in energy metabolism and angiogenesis, the treatment targets oxidative stress, mitochondrial respiration, UPS and angiogenesis using Cu complexes (Ge et al., 2022).