PDE3B and urinary bladder cancer: For instances, the phosphodiesterase 3B has been confirmed to increase the sensitivity of Cu ionophore to bladder cancer cells (Feng et al., 2024); the methyltransferase METTL16 is reported to promote FDX1 mRNA stability via m6A modification and FDX1 accumulation to enhance the sensitivity of elesclomol treatment in gastric cancer (Sun et al., 2023).