Disulfiram: DSF is a dithiocarbamate compound that treats alcohol dependence by targeting aldehyde dehydrogenase (ALDH), while acid condition reduces DSF to diethyldithiocarbamate (DTC) and invests the capacity to combine Cu(II) (Viola-Rhenals et al., 2018); DTC-Cu(II) complex induces lethal effects in ALDH+ and nuclear protein localization 4 positive (NPL4+) cancer cells combined with Cu overload (Skrott et al., 2017; Huang et al., 2016). The gene discussed is LDHA; the disease is alcohol dependence.