The combined effect of high glucose and iron levels will induce the expression of glucose-regulated protein 78 (GRP78) which causes the mucorales to invade and damage human endothelial cells [6]. The use of corticosteroids as a part of the COVID-19 treatment regime also further suppresses the immune system and contributes to hyperglycemia, rendering a more favorable environment for the invasion and growth of the mucorales. This evidence concerns the gene HSPA5 and Hyperglycemia.