Using an M1‐like macrophage‐specific 12/15‐LOX knockout (KO) murine model of heart failure, Kain et al. (2018) recently described reduced cardiac (left ventricle) SPMs in response to heart failure in 12/15‐LOX KO mice in comparison to wild‐type mice (8% of all oxylipins vs. 17%), with a reduction of D‐series resolvins, protectins and maresins by 70% in comparison to wild‐type mice (Kain et al., 2024). Here, CD59 is linked to heart failure.