further describe increased populations of splenic and cardiac (left ventricle) F4/80 Ly6Clo macrophages, CD4+ cells—specifically CD4 + Foxp3+ regulatory T cells, and neutrophils in 12/15‐LOX KO mice in comparison to wild‐type mice in a model of chronic heart failure (Kain et al., 2024). This evidence concerns the gene CD4 and congestive heart failure.