Regardless, the changes in viral‐specific antibody isotypes (N‐specific IgM) and effector functions (variant‐specific neutralization, although not unique between mAB and control), indicate that re‐infection with Omicron or other variants occurred in at least 4/5 of these patients (particularly as none of them received a bivalent booster vaccine). The gene discussed is CD40LG; the disease is infection.