Our findings indicate that radiologist-derived lesion volume estimations closely matched WMH measurements in patients with PSA values less than 10 ng/mL, PI-RADS 4 lesions, gland volumes not exceeding 58 mL, and those without high-grade PCa (≥ GG4) or extraprostatic extension on WMH. The gene discussed is KLK3; the disease is posterior cortical atrophy.