In the univariate analysis, the significant prognostic factors for poor OS were age > 70 years, ICGR15 > 15%, AFP > 10 (ng/mL), DCP > 400 mAU/mL, Child–Pugh B classification, multiple tumors, tumor > 40 mm, microvascular invasion, extrahepatic metastasis, liver cirrhosis, open liver resection, major hepatectomy, blood loss > 500 mL, ABC < 951, ALBI grade ≥ 2, GNRI < 100, PNI < 45, and CONUT score ≥ 3 were. The gene discussed is AFP; the disease is cirrhosis of liver.