In the univariate analysis, the significant prognostic factors for poor RFS included viral hepatitis status, ICGR15 > 15%, AFP > 10 ng/mL, DCP > 400 mAU/mL, Child–Pugh B classification, multiple tumors, microvascular invasion, extrahepatic metastasis, liver cirrhosis, open liver resection, operative time > 400 min, blood loss > 500 mL, ABC < 951, ALBI grade ≥ 2, GNRI < 100, PNI < 45, and CONUT score ≥ 3. This evidence concerns the gene AFP and viral hepatitis.