To determine whether different PDAC driver mutations impact the morphogenesis of distinct organoid phenotypes30, we analysed, in addition to PDAC cell lines generated from KC mouse models, a panel of primary PDAC cells (n = 18 PDAC mouse lines) derived from tumours harbouring KrasG12D and Cdkn2a (n = 6 lines) or Trp53 (n = 6 lines) deletions as well as tumours with a Pik3caH1047R activating mutation31 (n = 6 lines). Here, CDKN2A is linked to keratoconus.