NFKB1 and intervertebral disk degenerative disorder: More recently, Ohnishi et al. found that AdipoRon, an agonist of adiponectin receptor, protected the IVD from degeneration in vitro and in vivo.51 In mechanism, AdipoRon reduced inflammation and ECM catabolism by activating the AMPK signaling and suppressed NF-κB signaling in IDD.