Recently, Cabral et al. reported that mentin-1 facilitated human NP cell proliferation, and inhibited IL-1β-induced NP cell degradation, primarily by activating PI3K/Akt signaling pathway.55 Additionally, omentin-1 was also found to alleviate interleukin-1β-meditated human NP cells senescence in a Sirt1-dependent manner and thus to protect against disc degeneration.56 The above studies suggested that omentin-1 exerted critical functions in mitigating IDD and showed the potential in the target therapy for IDD. This evidence concerns the gene SIRT1 and intervertebral disk degenerative disorder.