To investigate the impact of NSD2 on intestinal barrier function in DSS‐induced IBD, we examined the expression level and localisation of the tight junction protein 1 (ZO‐1) and epithelial cadherin protein (E‐cadherin) in Nsd2f/f and Nsd2Vil‐KO mice. The gene discussed is TJP1; the disease is inflammatory bowel disease.