The Nuf mouse model of ADH1 has a mutation (Leu723Gln) in the homologous CaSR Leu723 residue that similarly results in enhanced CaSR signaling17 with biochemical features of hypoparathyroidism, including hypocalcemia, inappropriately low plasma PTH, and hyperphosphatemia.17 The gene discussed is PTH; the disease is hypoparathyroidism.