A spontaneous mouse model of ADH1, the Gprc2aNuf mouse (referred to as Nuf), has a GOF Leu723Gln Casr mutation and manifests hypocalcemia, hyperphosphatemia, reduced serum PTH and ectopic calcifications most notably in the ocular lens, but lacks hypercalciuria.17 This evidence concerns the gene CASR and hyperphosphatemia.