A spontaneous mouse model of ADH1, the Gprc2aNuf mouse (referred to as Nuf), has a GOF Leu723Gln Casr mutation and manifests hypocalcemia, hyperphosphatemia, reduced serum PTH and ectopic calcifications most notably in the ocular lens, but lacks hypercalciuria.17 The gene discussed is ADH1A; the disease is hyperphosphatemia.