The absence of the N terminus may prevent the generation of soluble APP that inhibits β-secretase (Obregon et al., 2012; Peters-Libeu et al., 2015; Willem et al., 2015), and therefore the samples expressing these NNC isoforms may potentially lack a protective mechanism limiting amyloid-β plaque formation, which could contribute to the progression of DLB. This evidence concerns the gene APP and Lewy body dementia.