PLK1 and neoplasm: While PLK1 inhibition in experimental models shows potent antitumoral effects in vitro and in vivo, translation to the clinic has been curbed by modest antitumor activity, tumor relapse, and frequent lack of response (Frost et al, 2012; Stadler et al, 2014; Ellis et al, 2015; Awad et al, 2017; Craig et al, 2022).