PLK1 and melanoma: The specific induction of apoptosis in melanoma cells versus melanocytes (Schmit et al, 2009) has reinforced interest in targeting PLK1 with small molecules (BI 2536 [Jalili et al, 2011; de Oliveira et al, 2012], BI 6727 [Cholewa et al, 2017]) and launching clinical trials (BI 6727 [Lin et al, 2014] and other inhibitors, reviewed in Chiappa et al [2022]).