There was an increased frequency of RBD+/S1+ IgM+ unswitched MBCs following 2 and 3+ doses in SLE patients (Fig. 4B and C), and an increase in and RBD+/S1+ IgM+ DN B cells after two doses (Supplementary Fig. 4C and D). This evidence concerns the gene CD40LG and systemic lupus erythematosus.