Analysis of the longitudinal cohort confirmed that although the levels of RBD-specific IgA and IgG were significantly increased in SLE patients after vaccination, the medians of IgG and IgA titres were higher in healthy compared to SLE patients even after 3+dose (titre median after 3+ doses: RBD IgG HC = 74.2k vs SLE = 37.5k; IgA HC = 704 vs SLE = 212.1) (Fig. 1D). The gene discussed is CD79A; the disease is systemic lupus erythematosus.