Strikingly, 43% (12 of 28) of these disease modifying genes (e.g. BRD9, CEP72, EXOC3, TPPP, ZDHHC11) reside in the Chr5 LG4 neighborhood depicted in Figure 3A, and what’s more, the expressions of CEP72, EXOC3, TPPP and ZDHHC11 were identified as the four most highly associated with CF severity genome wide. The gene discussed is TPPP; the disease is cystic fibrosis.