Disease-specific patterns of TSPO signals have been detected in the skull within stroke, multiple sclerosis and neurodegenerative disease patients.36 In a study performed by Hadjikhani et al. 40 investigating the inflammatory correlates of migraine with visual aura, TSPO-PET signal was elevated within the meninges and skull bone marrow (parameningeal tissue) overlying the occipital lobe. Here, TSPO is linked to multiple sclerosis.