COBL and Retinal dystrophy: Most of these loci encompass variants previously linked to retinal layer thickness parameters (including around LINC00461, TSPAN10, and COBL) (Gao et al. 2019, Currant et al. 2021, 2023) while a subset of them has also been linked to monogenic retinal disorders [including RDH5 (retinal dystrophy), TYR (albinism), and GNB3 (congenital stationary night blindness)] (Table 2; Supplementary Table S1).