VEGFA and periapical granuloma: Additionally, VEGF-positive inflammatory cells were observed in periapical granulomas, but their number decreased with the increase in epithelial components of the lesions.26Moreover, the lowest level of VEGF immunoexpression was observed in lesions with few inflammatory infiltrates.25In contrast to these findings, a previous study found that inflammation and VEGF expression are negatively correlated in periapical granulomas.29In addition, radicular cysts and residual cysts showed strong epithelial expression of VEGF, regardless of the level of inflammatory infiltrate.28