This hypoxia affects many cellular processes, including proliferation, angiogenesis, apoptosis, necrosis, and cell survival.9VEGF has been identified as a key downstream target of HIF-1α.7A complex interaction between cells, cytokines, and other inflammatory factors may contribute to the development of radicular cysts and periapical granulomas. The gene discussed is HIF1A; the disease is dental pulp disorder.