The present results indicating a significant correlation between HIF-1α and VEGF in the radicular cysts and periapical granulomas provide novel insights into the pathogenesis of these odontogenic lesions and support the hypothesis that HIF-1α, a marker of hypoxia, may trigger or enhance the production of VEGF.10The findings suggest that these lesions may expand and persist under hypoxic conditions, where the activation of HIF-1α leads to the upregulation of VEGF, causing new blood vessels to form to meet the metabolic demands of cystic or granulomatous tissue. This evidence concerns the gene HIF1A and dental pulp disorder.