Although the mechanisms of necrotic apoptosis in ischemic stroke have been explored, this study further deepened the understanding of stroke pathogenesis by focusing on the specific roles of RIPK1 and RIPK3, such as revealing how RIPK1 and RIPK3 affect the inflammatory response after stroke, the process of cell death, and the resilience of neurons. Here, RIPK3 is linked to ischemic stroke.