RIPK3 and heart failure: More and more studies have shown that [21, 22], programmed necrosis is involved in the onset and progression of diversified cardiovascular diseases, such as I/R injury, atherosclerosis, heart failure, etc. Animal experiments and clinical studies have shown [23, 24] that RIPK1 and RIPK3 are core factors involved in the pathological processes of cell necrosis and apoptosis.