EZH2 and cancer: Again, for each cancer we found a list of well-established cancer-related genes, e.g. RELA and HDAC4 in MM (Supplementary Fig. S5A), MYH9 and AKT1 in BC (Supplementary Fig. S5C), ATXN3 in PrC (Supplementary Fig. S5E), RECQL4 and EZH2 in CRC (Fig. S5G), and FN1 and HIF1A in PaC (Supplementary Fig. S5I), but also a set of novelly defined cancer-related genes, including CSNK2A1 and FBXW11 in MM (Supplementary Fig. S5A), HIST1H3A, HIST1H2BB and GOLGA2 in BC (Supplementary Fig. S5C), PIH1D1 in CRC (Supplementary Fig. S5G), and TMPO in PaC (Supplementary Fig. S5I).