HUWE1 and cancer: The remainder genes were: KIAA1429, a well-established oncogene [56]; CFTR, a tumour suppressor in intestinal cancer [57]; HUWE1, CUL1, CUL7, and OBSL1, encoding proteins involved in ubiquitin-ligase binding, a pathway often deregulated in cancers; EP300, which encodes for a histone acetyl-transferase and is a well-established tumour suppressor [58]; XPO1, which has a broad cancer involvement [59]; CDC5L, which is a well-established oncogene [60, 61]; and HNRNPL and HNRNPU, which encode for proteins involved in RNA metabolism, but whose involvement in cancer is just starting to be elucidated.