Such genes included well-established cancer-related genes, like XPO1, MDM2 and NRAS for MM (Fig. 4A), MYC, SIRT7, and CDK9 for BC (Fig. 4C), ESR2, YAP1, and HRAS for PrC (Fig. 4E), SMAD3, RUNX1, and NOTCH1 for CRC (Fig. 4G) and CHD4, CDK2, and MCM7 for PaC (Fig. 4I), but also genes whose involvement in the specific cancer in which we defined them as hubs was never assessed before. The gene discussed is SMAD3; the disease is breast cancer.