NR2C2 encodes for a nuclear receptor that was recently shown to function either as an oncosuppressor [53] or as an oncogene [54] based on the specific tumour type analysed, while PRPF8 encodes for a protein involved in mRNA splicing and its expression was recently demonstrated to increase the aggressiveness of HCC [55]. The gene discussed is PRPF8; the disease is neoplasm.