The remainder genes were: KIAA1429, a well-established oncogene [56]; CFTR, a tumour suppressor in intestinal cancer [57]; HUWE1, CUL1, CUL7, and OBSL1, encoding proteins involved in ubiquitin-ligase binding, a pathway often deregulated in cancers; EP300, which encodes for a histone acetyl-transferase and is a well-established tumour suppressor [58]; XPO1, which has a broad cancer involvement [59]; CDC5L, which is a well-established oncogene [60, 61]; and HNRNPL and HNRNPU, which encode for proteins involved in RNA metabolism, but whose involvement in cancer is just starting to be elucidated. This evidence concerns the gene HUWE1 and neoplasm.