Looking at the overall network scores for all gene classes throughout the tumours analysed (Supplementary Tables S2-S3), we found that they were, as expected, higher in those cancers known to have higher mutational rates, i.e. PrC and CRC, and lower in those known to have a lower mutational rate, i.e. BC and PaC (Fig.2B, Supplementary Fig. S2B and S2C) [35]. This evidence concerns the gene PPRC1 and breast cancer.