Additionally, c-JUN—an AP-1 family transcription factor36—lymphotoxin beta receptor (LTBR),37 interleukin (IL)-7, or C-C motif chemokine ligand (CCL)1938 have been shown to mitigate CAR-T cell exhaustion, and their overexpression can enhance tumor elimination ability in various studies. Here, JUN is linked to neoplasm.