CRP and atherosclerosis: Despite this robust association on a population level, evidence suggests that measuring hsCRP may have limited additional value in predicting risk of individual patients in primary prevention.4,6 This limitation may be partly due to the non-specific nature of CRP, which can be elevated in various inflammatory conditions beyond atherosclerosis.21 Moreover, Mendelian randomization studies have demonstrated that plasma hsCRP levels are not causally related to ASCVD: while genetically predicted CRP correlates with plasma hsCRP levels, it is not associated with ASCVD events.22–24