NPPB and cardiac hypertrophy: Upon pressure overload, similar levels of cardiac hypertrophy were detected in both WT and csKeap1KO mice as evidenced by a significant increase in both heart and cardiomyocyte size, and increased mRNA expression levels of hypertrophic markers, such as atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP; Figure 3D–G).