GPR55 and depressive disorder: Recently, studies have implicated GPR55 in the mechanisms of action of CBD.108 Evidence from Zhang et al. showed that treatment with CBD alleviated neurobehavioral abnormalities in maternal immune activation (MIA) mice by inhibiting the lipid lysophosphatidylinositol (LPI)-GPR55 signaling pathway, and a GPR55 antagonist (CID16020046) mimicked the effect of CBD on MIA mice and alleviated depression- and anxiety-like behaviors in MIA offspring.109