In line with our in vitro results, data from orthotopic BCa models using T24‐CIS cells showed that the R180A and Q275A mutations in Ins‐TACO1, but not the R196A mutation, restored MTCO1 expression levels and cisplatin resistance following TACO1 knockdown (Figure 7G,H; Figure S9R, Supporting Information). The gene discussed is INS; the disease is in situ carcinoma.