Previous research reported that TACO1 decrease causes a significant reduction in the expression of MTCO1 in mice.[16] Similarly, we have found that TACO1 knockdown inhibited MTCO1 expression in BCa‐CIS cells, while TACO1 overexpression enhanced the expression of MTCO1 in wild‐type J82 cells (Figure 2D; Figure S3C, Supporting Information), which is a crucial component of complex IV. Here, MT-CO1 is linked to in situ carcinoma.