For instance, circSamd4 promotes Vcp mitochondrial translocation to reduce mtROS in cardiomyocyte cells,[34] and circPUM1 enhances OXPHOS by maintaining mitochondrial homeostasis in esophageal squamous cell carcinoma.[34] Interestingly, the mitochondrial localization of circFOXK2 observed in BCa cells contrasts with its previously reported nuclear or cytosolic localization.[35] In BCa cells, circFOXK2 acts as a scaffold for TACO1‐HSP90β interaction, facilitating the mitochondrial translocation of TACO1. This evidence concerns the gene VCP and esophageal squamous cell carcinoma.