In hepatocellular carcinoma (HCC), CDC20 expression showed a significant correlation with immune infiltration of B cells, neutrophils, macrophages, and myeloid dendritic cells.[24, 25] Moreover, the CDC20 protein has been associated with the tumor mutation burden, immune checkpoint molecules, tumor microenvironment, and immunological infiltration in ccRCC.[26] However, APC‐dependent molecular mechanism of CDC20 in controlling RCC tumor immunity remains largely unknown. This evidence concerns the gene CDC20 and renal cell carcinoma.