VHL and nonpapillary renal cell carcinoma: PBRM1 has been found to be mutated in up to 41% of clear cell renal cell carcinoma (ccRCC), making it the second most commonly mutated gene after VHL in ccRCC.[2] Additionally, PBRM1 mutation is also observed in several other malignancies, including chordomas (11%–59%), cholangiocarcinomas (12%–23%), and non‐small cell lung cancers (≈3%).