FANCD2 and mismatch repair cancer syndrome 1: A more detailed analysis of the 83-channel indel pattern revealed that when compared toMSH2-/- single knockout, the MSH2-/- FANCD2-/- line displays an increase in 2 bp deletions in two-nucleotide repeats > 6 repeat units (Figure 3D), which are characteristic of signature ID12 (Figure 3E), as well as an increase in 1 bp deletions (mostly T) at homopolymers, which are characteristic of signature ID2 and are typical of MMR deficiency (54) (Figure 3E).