A more detailed analysis of the 83-channel indel pattern revealed that when compared toMSH2-/- single knockout, the MSH2-/- FANCD2-/- line displays an increase in 2 bp deletions in two-nucleotide repeats > 6 repeat units (Figure 3D), which are characteristic of signature ID12 (Figure 3E), as well as an increase in 1 bp deletions (mostly T) at homopolymers, which are characteristic of signature ID2 and are typical of MMR deficiency (54) (Figure 3E). This evidence concerns the gene MSH2 and mismatch repair cancer syndrome 1.