From tests with different categories of antihypertensives, hypertension in GPMur mice responded best to direct arterial vasodilator hydralazine, suggesting that vasodilator deficiency is the leading cause of “GPMur/AE1-triggered hypertension.” In conclusion, we showed that GPMur/increased AE1 predisposed hypertension risks. This evidence concerns the gene SLC4A1 and hypertensive disorder.