PNPO and Miyoshi myopathy: Interestingly, patients with MM have higher ROS levels and protein oxidation compared to healthy individuals and those with MGUS.[43, 44, 45] In our study, we discovered that PNPO oxidizes DVL3 at the M282 site, which increases its binding to GSK3β and prevents β‐catenin from being degraded by the proteasome‐ubiquitin complex.