BRD8 can also bind non‐histone proteins, such as the acetylated from of the N‐terminus of TWIST1 to recruit the rest of NuA4 to promote the epithelial‐mesenchymal transition and metastasis.[34] Mutations in BRD8 are relatively rare, and are sporadically distributed across many different cancer types instead of being concentrated in a single cancer,[68] suggesting BRD8 is playing an accessory role in tumorigenesis. This evidence concerns the gene TWIST1 and cancer.