The greater prevalence of higher severity CAA in the E280A Colombian cases might therefore be at least partially due to the higher-codon mutation location, greater proportion with Hispanic ethnicity and greater likelihood of hypercholesterolemia in Colombia as compared to the United States,27 although the current set of Colombian subjects had a lower APOE- ε4 carriage rate. This evidence concerns the gene APOE and familial hypercholesterolemia.