NR3C2 and hypertensive disorder: The findings also suggest that in cases of comorbid pain and hypertension, where a ’blood pressure-related hypoalgesia’ phenomenon is observed (see the introduction), antihypertensive medications with diuretic effects (such as thiazide diuretics, mineralocorticoid receptor blockers, calcium channel blockers, and α1-adrenergic blockers) should be avoided, as they may increase central hypovolemia.