Consequently, therapeutic strategies explored against prion diseases include the reduction of the PRNP expression, stabilization or capture of PrPC, use of antibodies against either normally folded or misfolded forms of the prion protein, blocking the conversion of PrPC into PrPSc, inhibition of PrPSc aggregation or disaggregation of existing fibrils, among others [2,3,7,8] (Fig 1). Here, PRNP is linked to prion disease.