IFNG and neoplasm: This is perhaps best exemplified in the setting of cancer where IFN-γ-producing γδT1 have been shown to play a critical role in tumor elimination (He et al., 2010; Gao et al., 2003; Girardi et al., 2001), while γδT17 subsets promote tumor growth and metastasis (Coffelt et al., 2015; Wu et al., 2014; Rei et al., 2014; Wakita et al., 2010).