APP and Alzheimer disease: Besides, the experiment using the postmortem brain samples from AD patients and age-matched non-AD patients demonstrated that impaired glucose metabolism inhibited nonamyloidogenic α-secretase processing of APP via the peroxisome proliferator activated receptor gamma coactivator 1 alpha/forkhead box protein O3a (PGC-1α/FoxO3a) pathway, thus promoting Aβ generation [62].