Considering that HIF-1α is associated with multiple pathological features of AD and microglia is an important macrophage in the brain, it is worth to investigate whether Gln in microglia can also influence the release of pro- and anti-inflammatory factors via the α-KG-JMJD3 or HIF-1α pathway to delay the development of AD. This evidence concerns the gene HIF1A and Alzheimer disease.