A previous study has found that the overexpression of KDM5B triggered mitochondrial glucose and lipid metabolism disorder and oxidative stress via transcriptional inhibition of sirtuin 3 expression by demethylating H3K4me3 or inactivation of AMP-activated protein kinase/sirtuin 3 pathways in the models of diabetic peripheral neuropathy model [173]. Here, SIRT3 is linked to Disorder of lipid metabolism.