In this study, we examined the AHN levels in four animal models of neurological diseases: the amyloid precursor protein (APP) and presenilin 1 (PS1) transgenic mice for Alzheimer’s disease, neuroinflammation induced by intracerebroventricular (i.c.v.)injection of lipopolysaccharide (LPS), learned helplessness (LH) and chronic restraint stress (CRS) to mimic stress and MDD (Supplementary Fig. 1). Here, PSEN1 is linked to early-onset autosomal dominant Alzheimer disease.