CD8A and Insulin resistance: Notably, the frequency of insulin-specific CD8 T cells positively correlated with HOMA-IR (r = 0.54, p = 0.01) (Fig. 3G) and Matsuda index (r = -0.56, p = 0.009) (Supplementary Fig. 8) [29], suggesting a link between insulin resistance and insulin-specific CD8 T cells.