GAD2 and Insulin resistance: This enrichment positively correlated with HOMA-IR (r = 0.56, p = 0.01) (Fig. 3C) and Matsuda index (r = -0.54, p = 0.01) (Supplementary Fig. 6B) [29], suggesting a specific link between insulin resistance and anti-GAD65-specific CD8 T cells with a memory phenotype.