CDH1 and neoplasm: Notably, despite having responders and non-responders in the combination groups (Figure 4A), a significant overall reduction in E-cadherin+ tumor cells as a percentage of total DAPI+ cells was observed (Figure 4—figure supplement 1C), supporting a decrease in cellularity and an increase in tumor necrosis with the IR/CCR5i/αPD1 combination (Figure 3B and C).