CD86 and neoplasm: Taken together, these interactions support the hypothesis that trNK cells may improve tumor control via recruitment of cDC1 via XCR1, while promoting DC maturation via LIGHT-CD86 signaling (Zou and Hu, 2005) and supporting DC antigen presentation to both CD4+ and CD8+ T-cells via MIF-CD74 signaling (Basha et al., 2012; Figure 6E).