On the other hand, dendritic cell-secreted BAG6 could promote both survival and cytokine release of NK cells by binding to NKp30 (Simhadri et al., 2008) and directly signal to CD8 T-cells via CXCL16-CXCR6 (Di Pilato et al., 2021; Vella et al., 2021), thereby generating an anti-tumor feedforward loop (Figure 6E). Here, BAG6 is linked to neoplasm.