ITGAE and neoplasm: Using a combination of uniform manifold approximation and projection (UMAP) dimensionality reduction and manual gating, we found that more than two-thirds of tumor-infiltrating NK cells expressed the canonical markers of tissue residency CD103 and CD49a (Figure 4—figure supplement 1E and F), with the double positive population (hereafter referred to as bona fide trNK cells) being barely detectable in untreated mice and rising nearly 40-fold after treatment (Figure 4E).