In melanoma, NK-mediated expression of XCL1 is crucial for the migration of XCR1+ cDC1 and therefore the non-cytotoxic NK subsets in tumors may be vital for cDC1-mediated cross-presentation of tumor antigens to CD8 T-cells (Böttcher et al., 2018). The gene discussed is XCL1; the disease is neoplasm.