Kirchhammer et al. recently reported that a tissue-resident NK (trNK) cell population is induced in NSCLC in response to viral delivery of IL-12, which crucially supported type 1 conventional dendritic cell (cDC1) infiltration and increased DC-CD8+ T-cell interactions (Kirchhammer et al., 2022). This evidence concerns the gene CD8A and non-small cell lung carcinoma.