Given the negative prognosis associated with high CCL5 serum levels in human patients and its diverse functions in chemokine and paracrine signaling (Aldinucci et al., 2020), we hypothesized that inhibiting CCR5 rather than CCL5, in combination with radiotherapy and anti-PD1 IT, may improve tumor control via a multimodal approach. The gene discussed is CCR5; the disease is neoplasm.