In humans, localization of lesions in ONs or brainstem have been reported in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) as distinct MRI features allowing distinction of this encephalitis from other acquired CNS demyelinating diseases such as multiple sclerosis and aquaporin‐4‐seropositive neuromyelitis optica spectrum disorder.45, 49, 62. This evidence concerns the gene OMG and demyelinating disease of central nervous system.