MEFV and amyloidosis: Homozygosity for the variant p.M694V has been linked to severe disease and an increased risk of renal AA amyloidosis, particularly in North African Jews,6-8 whereas the 2 variants p.M680I and p.M694I are found in the Arab population, generally with a low risk of amyloidosis.9,10 In a recent study of a North African population from Algeria, p.M694I homozygosity was shown to be associated with the development of renal amyloidosis.11 In this study, we will assess the distribution of MEFV variants in the Jordanian population and determine which variant is associated with symptomatic disease.