This study derived four major ACE patterns in the Chinese population, which were ‘ACE1 (Verbal abuse + physical abuse pattern)’, ‘ACE2 (Exposure to sexual assault pattern)’, ‘ACE3 (Substance abuse + mental illness + violent treatment of mother or stepmother pattern)’, ‘ACE4 (Violent treatment of mother or stepmother + criminal acts in the family pattern)’, and the specific composition of each model is shown in eResults and Table 5 in Supplement. The gene discussed is ACE2; the disease is substance abuse.