Somatic RET rearrangements (as fusion genes with CCDC6, NCOA4, KIF5B, PRKAR1A, TRIM33 and other rarer partners) have now been found in 1–2% of non-small-cell lung cancers (NSCLC) and at lower prevalence in many other cancers including pancreatic, colon, breast and salivary gland (Ou & Zhu 2020). The gene discussed is PRKAR1A; the disease is non-small cell lung carcinoma.