EZH2 is currently known to regulate AML by repressing tumor suppressor genes such as CDKN2A (Xu et al., 2015), EGR1 (Tanaka et al., 2012), MIR139 (Stavast et al., 2022) and TXNIP (Ueda et al., 2014). The gene discussed is EZH2; the disease is acute myeloid leukemia.