However, MLL can fuse with multiple genes (such as AF9, AF4, AF10), leading to the aberrant activation of AML-related oncogenes (like HOXA9 and MEIS1), which enhances the proliferative capacity of AML cells (Pastore & Levine, 2016; Tsai & So, 2017). This evidence concerns the gene AFF1 and acute myeloid leukemia.